Styrene

Styrene

SCHEMBL7950784

C=C(C)C(=O)[O-].C=Cc1ccccc1.[Na+].[NaH]

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 known ✓ P00918 1/20 0.38
CA4 known ✓ P22748 1/20 0.38
PTGS2 known ✓ P35354 1/20 0.36
ALDH1A1 P00352 5/20 0.52
TSHR P16473 2/20 0.52
TDP1 Q9NUW8 2/20 0.41
AKR1C3 P42330 1/20 0.41
GLA P06280 1/20 0.41
FBP1 P09467 1/20 0.38
HPGD P15428 1/20 0.38
CYP3A4 P08684 1/20 0.38
KDM4E B2RXH2 1/20 0.37
RECQL P46063 2/20 0.36
CYP2C19 P33261 1/20 0.36
AKT1 P31749 1/20 0.35
HDAC3 O15379 1/20 0.35
TNKS O95271 1/20 0.35
HDAC4 P56524 1/20 0.35
HDAC1 Q13547 1/20 0.35
HCAR2 Q8TDS4 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Styrene SCHEMBL1728767 0.98 ALDH1A1 (0.54) ALDH1A1TSHRTDP1AKR1C3GLA
Styrene SCHEMBL2711946 0.94 ALDH1A1 (0.54) ALDH1A1TSHRTDP1AKR1C3GLA
Styrene SCHEMBL1172412 0.86 ALDH1A1 (0.58) ALDH1A1TSHRTDP1AKR1C3GLA
Styrene SCHEMBL5550875 0.86 ALDH1A1 (0.58) ALDH1A1TSHRTDP1AKR1C3GLA
Methacrylic Acid SCHEMBL460576 0.86 ALDH1A1 (0.50) ALDH1A1TSHRTDP1GLAHPGD
Styrene SCHEMBL29139874 0.86 ALDH1A1 (0.41) ALDH1A1TSHRTDP1AKR1C3GLA
Styrene SCHEMBL76985 0.84 ALDH1A1 (0.61) ALDH1A1TSHRTDP1AKR1C3GLA
Styrene SCHEMBL6040755 0.84 ALDH1A1 (0.61) ALDH1A1TSHRTDP1AKR1C3GLA
Styrene SCHEMBL9459294 0.84 ALDH1A1 (0.61) ALDH1A1TSHRTDP1AKR1C3GLA
Styrene SCHEMBL7753037 0.84 ALDH1A1 (0.61) ALDH1A1TSHRTDP1AKR1C3GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6333039-B1 Opaque skin sanitizing composition GOJO INDUSTRIES, INC. 2001-12-25 US claimed
US-6333039-B1 Opaque skin sanitizing composition GOJO INDUSTRIES, INC. 2001-12-25 US disclosed