Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTRA1 | Q92743 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | KLK7 | P49862 | 2/20 | 0.35 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.34 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.34 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.34 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.34 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7951901 | 0.85 | CTSL (0.32) | MAPTCACNA1BCTSLMMP1MMP2 | |
| SCHEMBL7949581 | 0.69 | CXCR4 (0.38) | CA1CA2 | |
| SCHEMBL7938432 | 0.68 | ABCB1 (0.61) | HTRA1ITGB3ITGA2BMAPTABCB1 | |
| SCHEMBL30135128 | 0.68 | MEN1 (0.49) | HTRA1ITGB3ITGA2BMAPTABCB1 | |
| SCHEMBL7948016 | 0.67 | POLB (0.38) | MAPTKLK7MEN1KMT2AMMP3 | |
| SCHEMBL7982206 | 0.67 | POLB (0.36) | KLK7KMT2ACTSLMMP1MMP2 | |
| SCHEMBL8058852 | 0.66 | TPSAB1 (0.43) | MAPTCACNA1BFOLH1TPSAB1TPSD1 | |
| SCHEMBL7598385 | 0.66 | TRPM8 (0.44) | ITGB3ITGA2BMAPTABCB1KLK7 | |
| SCHEMBL5855814 | 0.65 | HTT (0.49) | ITGB3ITGA2BMAPTABCB1KLK7 | |
| SCHEMBL7596349 | 0.65 | TPSAB1 (0.44) | HTRA1ITGB3ITGA2BMAPTABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |