Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.32 |
| ▸ | CTSS | P25774 | 2/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.32 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7951899 | 0.85 | HTRA1 (0.37) | CTSLCACNA1BMAPTMMP1MMP2 | |
| SCHEMBL7948614 | 0.76 | POLB (0.40) | NPC1RAB9APOLBMAPT | |
| SCHEMBL7992034 | 0.75 | F2 (0.33) | CPB2 | |
| SCHEMBL7947164 | 0.74 | PLA2G2A (0.37) | NPC1RAB9APOLBMAPT | |
| SCHEMBL7948256 | 0.73 | CPB2 (0.36) | CPB2 | |
| SCHEMBL7946077 | 0.72 | POLB (0.35) | NPC1RAB9APOLBMAPTMMP1 | |
| SCHEMBL7938360 | 0.72 | POLB (0.36) | NPC1RAB9APOLBMAPT | |
| SCHEMBL7947094 | 0.72 | POLB (0.37) | NPC1RAB9APOLBMAPTMMP1 | |
| SCHEMBL7948016 | 0.71 | POLB (0.38) | NPC1RAB9APOLBMAPTMMP3 | |
| SCHEMBL7945107 | 0.71 | POLB (0.36) | NPC1RAB9APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010035032-A1 | CALCIUM ION CHANNEL MODULATORS & USES THEREOF | LECTUS THERAPEUTICS LIMITED (GB) | 2010-04-01 | — | — | WO | disclosed |
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |