Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.35 |
| ▸ | HRH1 | P35367 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PRNP | P04156 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963779 | 0.79 | MAPT (0.41) | MAPTTP53LMNAMEN1KMT2A | |
| SCHEMBL7963780 | 0.77 | AKT1 (0.37) | MAPTTP53LMNAACACBMEN1 | |
| SCHEMBL7953566 | 0.69 | OPRM1 (0.39) | MAPTLMNAMEN1KMT2ASMN1; SMN2 | |
| Maleic Acid SCHEMBL7967346 | 0.69 | RAB9A (0.42) | MEN1KMT2AKDM4ESMN1; SMN2RAB9A | |
| Fumaric Acid SCHEMBL7967350 | 0.69 | RAB9A (0.42) | MEN1KMT2AKDM4ESMN1; SMN2RAB9A | |
| SCHEMBL7962232 | 0.68 | HTR1A (0.34) | AKT1AKT2 | |
| SCHEMBL25171674 | 0.66 | HDAC4 (0.49) | TP53LMNAAKT1AKT2NPSR1 | |
| SCHEMBL7953787 | 0.64 | KDM4E (0.37) | MAPTTP53LMNAMEN1KMT2A | |
| SCHEMBL7962696 | 0.63 | LTA4H (0.35) | MAPTLMNAMEN1KMT2AKDM4E | |
| SCHEMBL3714809 | 0.62 | HPGDS (0.53) | TP53MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |