Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24325814 | 0.83 | DNM1 (0.46) | TSHRHTR2CSLC6A4ALDH1A1KDM4E | |
| SCHEMBL20715723 | 0.81 | SLC6A4 (0.49) | CHRNB2CHRNB4CHRNA3CHRNA4HTR2C | |
| SCHEMBL8193756 | 0.81 | HTR2C (0.43) | TSHRCHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7190668 | 0.77 | RIPK1 (0.57) | CHRNB2CHRNB4CHRNA3CHRNA4HTR2C | |
| SCHEMBL23699429 | 0.77 | CYP1A2 (0.51) | HTR2CSLC6A4HPGD | |
| SCHEMBL23719091 | 0.76 | CTSK (0.44) | HTR2CSLC6A4CTSS | |
| SCHEMBL23699255 | 0.76 | CTSK (0.44) | HTR2CSLC6A4CTSS | |
| SCHEMBL13215429 | 0.75 | SIGMAR1 (0.49) | L3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL23699386 | 0.73 | CTSS (0.47) | HTR2CSLC6A4ALDH1A1KDM4ECTSS | |
| SCHEMBL1529700 | 0.73 | ATM (0.43) | HTR2CSLC6A4CTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137462-A2 | METHODS FOR TREATING COGNITIVE DISORDERS USING INHIBITORS OF HISTONE DEACETYLASE | ENVIVO PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |
| WO-2008055068-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2008-05-08 | — | — | WO | disclosed |