Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974029 | 0.88 | ADORA3 (0.50) | NPC1ALDH1A1MAPTRAB9AMEN1 | |
| SCHEMBL7984937 | 0.87 | ADORA3 (0.52) | NPC1ALDH1A1MAPTRAB9AMEN1 | |
| SCHEMBL7974265 | 0.87 | MCHR1 (0.47) | POLBNPC1MAPTRAB9AMEN1 | |
| SCHEMBL7985249 | 0.85 | MAPT (0.48) | POLBNPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL7975241 | 0.85 | GAA (0.50) | POLBNPC1RAB9AHDAC1HDAC8 | |
| SCHEMBL7985033 | 0.83 | NLRP3 (0.46) | POLBNPC1ALDH1A1MAPTRAB9A | |
| SCHEMBL7988231 | 0.83 | NPC1 (0.47) | NPC1RAB9AKMT2AHDAC1HDAC8 | |
| SCHEMBL7992192 | 0.83 | HSD17B13 (0.46) | POLBMAPTMEN1KMT2AKDM4E | |
| SCHEMBL7985340 | 0.83 | NTRK1 (0.51) | NPC1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL7988029 | 0.83 | IDO1 (0.47) | POLBNPC1RAB9AHDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |