Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974029 | 0.96 | ADORA3 (0.50) | NPC1RAB9AADORA3HDAC1HDAC6 | |
| SCHEMBL7975241 | 0.89 | GAA (0.50) | NPC1RAB9AADORA3HDAC1HDAC6 | |
| SCHEMBL7985340 | 0.89 | NTRK1 (0.51) | NPC1RAB9AADORA3KMT2AKCNK9 | |
| SCHEMBL7984937 | 0.89 | ADORA3 (0.52) | NPC1RAB9AADORA3KMT2ACDK5 | |
| SCHEMBL7974265 | 0.88 | MCHR1 (0.47) | NPC1RAB9AADORA3HDAC1HDAC2 | |
| SCHEMBL7974581 | 0.87 | LMNA (0.51) | NPC1RAB9AADORA3HDAC1HDAC6 | |
| SCHEMBL7984694 | 0.86 | NR1H4 (0.53) | NPC1RAB9AHDAC1HDAC6HDAC2 | |
| SCHEMBL7973841 | 0.86 | RAB9A (0.47) | NPC1RAB9AHDAC1HDAC6HDAC2 | |
| SCHEMBL7984668 | 0.84 | POLB (0.49) | NPC1RAB9AADORA3MMP13 | |
| SCHEMBL7973996 | 0.83 | POLB (0.49) | NPC1RAB9AADORA3HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |