Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.39 |
| ▸ | EDNRB | P24530 | 6/20 | 0.38 |
| ▸ | EDNRA | P25101 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | DHPS | P49366 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | GLA | P06280 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7979128 | 0.90 | MAPT (0.41) | GPR84EDNRBEDNRAALDH1A1MAPT | |
| SCHEMBL7979433 | 0.82 | EDNRB (0.38) | GPR84EDNRBEDNRAALDH1A1DHPS | |
| SCHEMBL7997005 | 0.80 | EDNRA (0.52) | EDNRADHPS | |
| SCHEMBL7997022 | 0.79 | MAPT (0.41) | GPR84EDNRBEDNRAALDH1A1MAPT | |
| SCHEMBL7996807 | 0.78 | DHPS (0.53) | EDNRBEDNRADHPS | |
| SCHEMBL7993990 | 0.76 | RAB9A (0.44) | EDNRBEDNRAALDH1A1MAPTPOLB | |
| SCHEMBL7979093 | 0.76 | ALDH1A1 (0.47) | GPR84EDNRBEDNRAALDH1A1DHPS | |
| SCHEMBL7991615 | 0.75 | GPR84 (0.42) | GPR84EDNRBEDNRAALDH1A1DHPS | |
| SCHEMBL7997150 | 0.74 | GPR84 (0.42) | GPR84EDNRBEDNRAALDH1A1DHPS | |
| SCHEMBL7993553 | 0.73 | DHPS (0.50) | EDNRBEDNRADHPSPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001081338-A1 | SUBSTITUTED SULFONYLAMINOPYRIMIDINES | ACTELION PHARMACEUTICALS LTD (CH) | 2001-11-01 | — | — | WO | disclosed |