Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | EDNRA | P25101 | 7/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | EDNRB | P24530 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 4/20 | 0.37 |
| ▸ | DHPS | P49366 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7997147 | 0.92 | GPR84 (0.40) | GPR84TNK2MEN1KMT2AAXL | |
| SCHEMBL7991615 | 0.90 | GPR84 (0.42) | GPR84ALDH1A1EDNRAPDE4AEDNRB | |
| SCHEMBL7991613 | 0.81 | GPR84 (0.40) | GPR84ALDH1A1EDNRAEDNRBAXL | |
| SCHEMBL7997005 | 0.77 | EDNRA (0.52) | EDNRADHPS | |
| SCHEMBL7979130 | 0.74 | GPR84 (0.39) | GPR84ALDH1A1EDNRAEDNRBDHPS | |
| SCHEMBL7993990 | 0.74 | RAB9A (0.44) | MEN1KMT2AALDH1A1EDNRAEDNRB | |
| SCHEMBL7979093 | 0.73 | ALDH1A1 (0.47) | GPR84ALDH1A1EDNRAEDNRBDHPS | |
| SCHEMBL7996807 | 0.73 | DHPS (0.53) | EDNRAEDNRBDHPS | |
| SCHEMBL7979433 | 0.72 | EDNRB (0.38) | GPR84ALDH1A1EDNRAPDE4AEDNRB | |
| SCHEMBL7997001 | 0.71 | EDNRA (0.51) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001081338-A1 | SUBSTITUTED SULFONYLAMINOPYRIMIDINES | ACTELION PHARMACEUTICALS LTD (CH) | 2001-11-01 | — | — | WO | disclosed |