Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 3/20 | 0.33 |
| ▸ | PTGIR | P43119 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7981921 | 0.88 | TSHR (0.40) | GAATDP1SMN1; SMN2KDM4ELMNA | |
| SCHEMBL7992900 | 0.87 | PTGIR (0.33) | HTTPTGIR | |
| SCHEMBL7981085 | 0.85 | CA12 (0.34) | KMT2AMEN1POLBLMNA | |
| SCHEMBL7981280 | 0.85 | PIN1 (0.40) | KMT2AMEN1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7969219 | 0.79 | KMT2A (0.34) | KMT2AMEN1TDP1POLB | |
| SCHEMBL7969242 | 0.73 | TP53 (0.41) | KMT2AMEN1TDP1ALDH1A1KDM4E | |
| SCHEMBL7944575 | 0.69 | ALDH1A1 (0.40) | TDP1ALDH1A1KDM4E | |
| SCHEMBL4313656 | 0.69 | TDP1 (0.51) | GAAKMT2AMEN1TDP1SMN1; SMN2 | |
| SCHEMBL27601299 | 0.68 | SMN1; SMN2 (0.51) | GAAKMT2AMEN1TDP1SMN1; SMN2 | |
| SCHEMBL7944573 | 0.68 | TDP1 (0.37) | TDP1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009133387-A1 | INDOLE- 3 -GLYOXYLAMIDE DERIVATIVES FOR USE AS CALCIUM ION CHANNEL MODULATORS | LECTUS THERAPEUTICS LIMITED (GB) | 2009-11-05 | — | — | WO | disclosed |