Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.46 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | VNN1 | O95497 | 2/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | PRKX | P51817 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974040 | 0.95 | KDM4E (0.51) | ADORA2AADORA3ADORA2BKDM4EADORA1 | |
| SCHEMBL7975241 | 0.90 | GAA (0.50) | ADORA2AADORA3ADORA2BADORA1FLT3 | |
| SCHEMBL7985033 | 0.88 | NLRP3 (0.46) | ADORA3KDM4EKCNK3KCNK9ALDH1A1 | |
| SCHEMBL7984200 | 0.88 | SMN1; SMN2 (0.53) | ADORA3KCNK3ALDH1A1CDC7DAPK3 | |
| SCHEMBL7974581 | 0.88 | LMNA (0.51) | ADORA3ALDH1A1FLT3 | |
| SCHEMBL7988029 | 0.88 | IDO1 (0.47) | ADORA3FLT3 | |
| SCHEMBL7992620 | 0.86 | NPC1 (0.53) | KDM4EALDH1A1YTHDC1 | |
| SCHEMBL7984937 | 0.85 | ADORA3 (0.52) | ADORA3KDM4EKCNK3KCNK9ALDH1A1 | |
| SCHEMBL7985560 | 0.85 | ADORA3 (0.52) | ADORA3KCNK3ALDH1A1VNN1KCNQ3 | |
| SCHEMBL7984965 | 0.85 | ALDH1A1 (0.57) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |