Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC8 | Q09428 | 1/20 | 0.42 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.37 |
| ▸ | CNOT7 | Q9UIV1 | 2/20 | 0.36 |
| ▸ | PARN | O95453 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | GNRHR | P30968 | 3/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.33 |
| ▸ | TACR2 | P21452 | 1/20 | 0.33 |
| ▸ | HRH2 | P25021 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974551 | 0.89 | CNOT7 (0.47) | CNOT7PARNP2RX7 | |
| SCHEMBL7985012 | 0.89 | ABCC8 (0.43) | ABCC8KCNJ11NR1H4CNOT7PARN | |
| SCHEMBL7991403 | 0.89 | ABCC8 (0.43) | ABCC8KCNJ11NR1H4CNOT7PARN | |
| SCHEMBL7984871 | 0.88 | ABCC8 (0.45) | ABCC8KCNJ11NR1H4CNOT7PARN | |
| SCHEMBL7992270 | 0.88 | ABCC8 (0.43) | ABCC8KCNJ11NR1H4CNOT7PARN | |
| SCHEMBL7974282 | 0.88 | ABCC8 (0.43) | ABCC8KCNJ11NR1H4CNOT7PARN | |
| SCHEMBL7974492 | 0.87 | ABCC8 (0.47) | ABCC8KCNJ11NR1H4CNOT7PARN | |
| SCHEMBL7988017 | 0.87 | KDM4E (0.43) | ABCC8KCNJ11HDAC6 | |
| SCHEMBL7984466 | 0.86 | HPGD (0.42) | ABCC8KCNJ11NR1H4NR1I2GNRHR | |
| SCHEMBL7985602 | 0.86 | SERPINE1 (0.45) | ABCC8KCNJ11P2RX7SERPINE1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |