Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.41 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.41 |
| ▸ | DUT | P33316 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7991545 | 0.90 | TSHR (0.48) | TP53RXFP1GAAMAPTAURKA | |
| SCHEMBL7974586 | 0.89 | GAA (0.52) | TP53RXFP1GAAMAPTP2RX7 | |
| SCHEMBL7974195 | 0.89 | GAA (0.48) | TP53RXFP1GAAMAPTP2RX7 | |
| SCHEMBL7985852 | 0.88 | TP53 (0.52) | TP53RXFP1GAAMAPTAURKA | |
| SCHEMBL7985012 | 0.88 | ABCC8 (0.43) | ABCC8KCNJ11HDAC1HDAC6 | |
| SCHEMBL7991403 | 0.88 | ABCC8 (0.43) | TP53ABCC8KCNJ11MAPT | |
| SCHEMBL7992270 | 0.87 | ABCC8 (0.43) | ABCC8KCNJ11HDAC1HDAC6 | |
| SCHEMBL7974282 | 0.87 | ABCC8 (0.43) | SERPINE1ABCC8KCNJ11HDAC1HDAC6 | |
| SCHEMBL7974492 | 0.86 | ABCC8 (0.47) | RXFP1GAAABCC8KCNJ11HDAC6 | |
| SCHEMBL7991877 | 0.86 | P2RX7 (0.47) | TP53RXFP1GAAMAPTP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |