Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morpholine SCHEMBL7985369 | 0.81 | NR1H4 (0.56) | SMN1; SMN2TP53NPC1RAB9AKMT2A | |
| Morpholine SCHEMBL7988982 | 0.78 | RAB9A (0.46) | SMN1; SMN2TP53NPC1RAB9ANPSR1 | |
| SCHEMBL7984700 | 0.76 | KDM4E (0.59) | TP53ALDH1A1L3MBTL1 | |
| SCHEMBL20830918 | 0.73 | KMT2A (0.67) | SMN1; SMN2TP53NPC1RAB9ASLC6A2 | |
| SCHEMBL5085785 | 0.72 | KMT2A (0.81) | SMN1; SMN2NPC1RAB9ASLC6A2SLC6A3 | |
| Morpholine SCHEMBL28263111 | 0.72 | TDP1 (0.45) | SMN1; SMN2NPC1RAB9ASLC6A2SLC6A3 | |
| SCHEMBL13034129 | 0.71 | ALDH1A1 (0.56) | SMN1; SMN2TP53NPC1RAB9AKMT2A | |
| SCHEMBL6670098 | 0.71 | L3MBTL1 (0.58) | SMN1; SMN2KMT2ATDP1ALDH1A1L3MBTL1 | |
| SCHEMBL6671241 | 0.71 | KMT2A (0.63) | SMN1; SMN2NPC1RAB9ASLC6A2SLC6A3 | |
| Morpholine SCHEMBL7989270 | 0.71 | PLA2G4B (0.59) | SMN1; SMN2TP53NPC1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |