Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 2/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.36 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.35 |
| ▸ | GPR132 | Q9UNW8 | 4/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7994940 | 0.92 | PTGES (0.52) | PTGESHTR1ADRD2PRKDCIKBKB | |
| SCHEMBL7984832 | 0.82 | PTGES (0.63) | PTGESL3MBTL1BRD4SGMS2MAPT | |
| SCHEMBL7996575 | 0.80 | PTGES (0.55) | PTGESPRKDCIKBKBBRD4SGMS2 | |
| SCHEMBL7994971 | 0.73 | PTGES (0.59) | PTGESHTR1ADRD2PRKDCSYK | |
| SCHEMBL7984591 | 0.73 | PTGES (0.61) | PTGESAPAF1L3MBTL1ALDH1A1POLB | |
| SCHEMBL7984763 | 0.71 | PTGES (0.54) | PTGESL3MBTL1ALDH1A1POLBMAPT | |
| SCHEMBL7996440 | 0.71 | PTGES (0.54) | PTGESL3MBTL1ALDH1A1POLBMAPT | |
| SCHEMBL7994951 | 0.71 | PTGES (0.56) | PTGESL3MBTL1ALDH1A1POLBMAPT | |
| SCHEMBL23876437 | 0.69 | PTGES (1.00) | PTGESHTR1AL3MBTL1ALDH1A1POLB | |
| SCHEMBL7996719 | 0.68 | PTGES (0.64) | PTGESAPAF1ALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001079209-A2 | DIAZAFLUORENONE IL-8 ANTAGONISTS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2001-10-25 | — | — | WO | disclosed |