Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.45 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7989420 | 0.90 | MET (0.45) | DHPSCYP3A4CYP2C19CYP1A2SMN1; SMN2 | |
| SCHEMBL7984769 | 0.90 | CLK4 (0.44) | DHPSL3MBTL1CLK4ALDH1A1SMN1; SMN2 | |
| SCHEMBL7988659 | 0.89 | P2RX7 (0.41) | DHPSCYP3A4CYP2D6CYP2C19CYP2E1 | |
| SCHEMBL7975267 | 0.89 | SMN1; SMN2 (0.46) | HPGDSALDH1A1SMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL7986327 | 0.89 | NPC1 (0.43) | DHPSCYP3A4CYP2D6CYP2C19CYP2E1 | |
| SCHEMBL7988934 | 0.87 | CYP1A2 (0.47) | DHPSCYP3A4CYP2D6CYP2C19CYP2A6 | |
| SCHEMBL7985334 | 0.87 | ABCG2 (0.46) | DHPSCLK1DYRK1AALDH1A1CYP11B1 | |
| SCHEMBL7974237 | 0.87 | KIF11 (0.42) | DHPSALDH1A1SMN1; SMN2LMNAMEN1 | |
| SCHEMBL7974441 | 0.87 | GRK2 (0.43) | DHPSDYRK1AHPGDSALDH1A1SMN1; SMN2 | |
| SCHEMBL7974043 | 0.87 | GBA1 (0.43) | DHPSCYP3A4CYP2D6CYP2C19L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |