Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 2/20 | 0.43 |
| ▸ | DHFR | P00374 | 2/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987245 | 0.87 | ROCK2 (0.47) | FYNDHFRSMN1; SMN2ALDH1A1 | |
| SCHEMBL7991814 | 0.80 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL7989347 | 0.80 | CYP11B1 (0.44) | ALDH1A1TSHRKMT2A | |
| SCHEMBL7987441 | 0.79 | MEN1 (0.49) | MEN1ALDH1A1KMT2A | |
| SCHEMBL7985129 | 0.74 | YTHDC1 (0.50) | — | |
| SCHEMBL7988530 | 0.74 | SMN1; SMN2 (0.46) | SMN1; SMN2MEN1ALDH1A1CYP3A4TSHR | |
| SCHEMBL7985719 | 0.74 | GAA (0.41) | KDM4ESMN1; SMN2MEN1ALDH1A1TSHR | |
| SCHEMBL5483136 | 0.74 | PKM (0.59) | ALDH1A1TSHR | |
| SCHEMBL7975372 | 0.73 | ALDH1A1 (0.51) | POLBSLC2A1SMN1; SMN2MEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7987445 | 0.72 | PKM (0.57) | ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6310070-B1 | FOR TREATING NEPHRITIS, IMPROVING PROTEINURIA DUE TO GLOMERULONEPHRITIS AND PREVENTING AGGRAVATION OF NEPHRITIS | JAPAN ENERGY CORPORATION (JP) | 2001-10-30 | — | — | US | disclosed |
| EP-0999211-A1 | NOVEL PURINE DERIVATIVES AND MEDICINAL USE THEREOF | JAPAN ENERGY CORPORATION (JP) | 2000-05-10 | — | — | EP | disclosed |