Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7998748 | 0.77 | CYP19A1 (0.41) | NFE2L2CYP19A1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8002652 | 0.73 | L3MBTL1 (0.43) | NFE2L2CYP1B1FBP1KMT2AL3MBTL1 | |
| SCHEMBL7918794 | 0.73 | NFE2L2 (0.62) | NFE2L2CYP19A1CYP1B1FBP1KMT2A | |
| SCHEMBL7918792 | 0.73 | NFE2L2 (0.62) | NFE2L2CYP19A1CYP1B1FBP1KMT2A | |
| SCHEMBL7990162 | 0.73 | ALDH1A1 (0.51) | NFE2L2CYP19A1FBP1KMT2AMEN1 | |
| SCHEMBL27980282 | 0.72 | CYP1B1 (0.53) | NFE2L2CYP19A1CYP1B1FBP1KMT2A | |
| SCHEMBL28813938 | 0.72 | CYP1B1 (0.53) | NFE2L2CYP19A1CYP1B1FBP1KMT2A | |
| SCHEMBL8001632 | 0.72 | MAPT (0.48) | NFE2L2FBP1SMN1; SMN2LMNAMAOB | |
| SCHEMBL7988653 | 0.72 | MAOB (0.41) | NFE2L2KMT2AALDH1A1LMNAMAOB | |
| SCHEMBL7907892 | 0.71 | NFE2L2 (0.62) | NFE2L2CYP19A1FBP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009120783-A1 | HIGH AFFINITY INHIBITORS OF HEPATITIS C VIRUS NS3/4A PROTEASE | THE JOHNS HOPKINS UNIVERSITY (US) | 2009-10-01 | — | — | WO | disclosed |