Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.44 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | DTYMK | P23919 | 1/20 | 0.39 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.39 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.39 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11795768 | 0.96 | CA1 (0.46) | GPR35CASP6CA1CA2TSHR | |
| Lithium Ion SCHEMBL29241856 | 0.96 | GPR35 (0.44) | GPR35CASP6CA1CA2TSHR | |
| SCHEMBL304470 | 0.84 | CASP6 (0.55) | GPR35CASP6TSHRDTYMKCES2 | |
| SCHEMBL11777964 | 0.84 | GPR35 (0.47) | GPR35CASP6TSHRDTYMKTXNRD1 | |
| Potassium Ion SCHEMBL4088712 | 0.83 | GPR35 (0.56) | GPR35TSHRALDH1A1CTSD | |
| SCHEMBL27501298 | 0.82 | CASP6 (0.53) | GPR35CASP6TSHRDTYMKCES2 | |
| SCHEMBL3278518 | 0.81 | ALDH1A1 (0.46) | GPR35CASP6TSHRDTYMKTXNRD1 | |
| SCHEMBL5576910 | 0.81 | LMNA (0.46) | GPR35CASP6TSHRALDH1A1LMNA | |
| SCHEMBL10689189 | 0.79 | ALDH1A1 (0.58) | GPR35CASP6ALDH1A1LMNACTSD | |
| SCHEMBL4103991 | 0.79 | GPR35 (0.56) | GPR35TSHRALDH1A1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000026603-A1 | NON-PRIMARY DETONATORS | ORICA EXPLOSIVES TECHNOLOGY PTY. LTD. (AU) | 2000-05-11 | — | — | WO | claimed |
| WO-2000026603-A1 | NON-PRIMARY DETONATORS | ORICA EXPLOSIVES TECHNOLOGY PTY. LTD. (AU) | 2000-05-11 | — | — | WO | disclosed |