Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 1/20 | 0.43 |
| ▸ | AGTR1 known ✓ | P30556 | 1/20 | 0.43 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.43 |
| ▸ | GABRB2 known ✓ | P47870 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.45 |
| ▸ | PCNA | P12004 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | THRA | P10827 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4108699 | 0.94 | GAA (0.66) | GAAALDH1A1GFERHSP90AB1CYP4F2 | |
| SCHEMBL3858898 | 0.81 | GAA (0.61) | GAAALDH1A1GFERHSP90AB1CYP4F2 | |
| SCHEMBL3668882 | 0.79 | GAA (0.72) | GAAALDH1A1GFERHSP90AB1CYP4F2 | |
| SCHEMBL29446278 | 0.79 | GAA (0.72) | GAAALDH1A1GFERHSP90AB1CYP4F2 | |
| SCHEMBL30716575 | 0.78 | ALOX5 (0.51) | GAAALDH1A1GFERPCNAHPGD | |
| SCHEMBL1746504 | 0.78 | ALOX5 (0.51) | GAAALDH1A1GFERPCNAHPGD | |
| SCHEMBL13014917 | 0.78 | ALDH1A1 (0.53) | GAAALDH1A1GFERHSP90AB1CYP4F2 | |
| Methyl Alcohol SCHEMBL27946196 | 0.77 | GAA (0.70) | GAAALDH1A1GFERHSP90AB1CYP4F2 | |
| SCHEMBL14768426 | 0.77 | GAA (0.70) | GAAALDH1A1GFERHSP90AB1CYP4F2 | |
| SCHEMBL14485394 | 0.77 | HSP90AB1 (0.66) | GAAALDH1A1GFERHSP90AB1CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001055139-A1 | ISOTHIAZOLE DERIVATIVES AND THEIR USE AS PESTICIDES | SYNGENTA LIMITED (GB) | 2001-08-02 | — | — | WO | disclosed |