Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.37 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7998680 | 0.86 | HTT (0.48) | HTTCYP11B1CYP11B2ALDH1A1POLB | |
| SCHEMBL7992008 | 0.80 | HTT (0.47) | HTTHTR1ADRD2ALDH1A1KMT2A | |
| SCHEMBL7998683 | 0.77 | HTT (0.53) | HTTHTR1ADRD2HRH3LMNA | |
| SCHEMBL7981094 | 0.75 | HTT (0.45) | HTTKMT2AMEN1LMNATDP1 | |
| SCHEMBL7995324 | 0.71 | HTT (0.55) | HTTMAPK1POLBLMNATDP1 | |
| SCHEMBL7995311 | 0.71 | CALM1 (0.44) | HTT | |
| SCHEMBL29995759 | 0.67 | CYP11B1 (0.65) | CYP11B1CYP11B2HRH4HRH3 | |
| SCHEMBL177863 | 0.67 | CYP11B1 (0.65) | CYP11B1CYP11B2HRH4HRH3 | |
| SCHEMBL7311175 | 0.67 | MAPK1 (0.65) | MAPK1HTR1ADRD2KMT2AMEN1 | |
| SCHEMBL1323646 | 0.67 | RAB9A (0.62) | MAPK1HTR1ADRD2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001009129-A2 | 1H-PIRIDO[3, 4-B]INDOL-1-ONE DERIVATIVES | NOVUSPHARMA S.P.A. (IT) | 2001-02-08 | — | — | WO | disclosed |