Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7995089 | 0.83 | HTT (0.54) | HTTL3MBTL1TDP1MAPTRAB9A | |
| SCHEMBL7998680 | 0.80 | HTT (0.48) | HTTNPC1SMN1; SMN2LTA4H | |
| SCHEMBL7998683 | 0.76 | HTT (0.53) | HTTLMNATSHRLTA4HEPHX2 | |
| SCHEMBL7992008 | 0.76 | HTT (0.47) | HTTL3MBTL1MAPTRAB9ANPC1 | |
| SCHEMBL7995327 | 0.75 | HTT (0.46) | HTTTDP1RAB9ALMNAMEN1 | |
| SCHEMBL7995324 | 0.70 | HTT (0.55) | HTTL3MBTL1TDP1MAPTRAB9A | |
| SCHEMBL7995311 | 0.70 | CALM1 (0.44) | HTTL3MBTL1KDM4E | |
| SCHEMBL28508353 | 0.69 | L3MBTL1 (0.53) | L3MBTL1TDP1MAPTRAB9ANPC1 | |
| SCHEMBL45228 | 0.66 | LMNA (0.50) | L3MBTL1TDP1RAB9ANPC1LMNA | |
| SCHEMBL9825918 | 0.65 | LMNA (0.49) | L3MBTL1TDP1RAB9ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001009129-A2 | 1H-PIRIDO[3, 4-B]INDOL-1-ONE DERIVATIVES | NOVUSPHARMA S.P.A. (IT) | 2001-02-08 | — | — | WO | disclosed |