Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7995089 | 0.93 | HTT (0.54) | HTTLTA4HSMN1; SMN2MAPK14 | |
| SCHEMBL7995327 | 0.86 | HTT (0.46) | HTTCYP11B1CYP11B2IKBKBALDH1A1 | |
| SCHEMBL7992008 | 0.82 | HTT (0.47) | HTTABCB1LTA4HSMN1; SMN2NPC1 | |
| SCHEMBL7981094 | 0.80 | HTT (0.45) | HTTLTA4HSMN1; SMN2NPC1 | |
| SCHEMBL7998683 | 0.80 | HTT (0.53) | HTTABCB1LTA4H | |
| SCHEMBL7995324 | 0.73 | HTT (0.55) | HTTLTA4HSMN1; SMN2MAPK14POLB | |
| SCHEMBL7995311 | 0.73 | CALM1 (0.44) | HTT | |
| SCHEMBL23715839 | 0.67 | CALM1 (0.39) | ALDH1A1GSK3B | |
| SCHEMBL9512609 | 0.67 | CALM1 (0.67) | LTA4HCYP11B1CYP11B2POLB | |
| SCHEMBL432308 | 0.67 | CALM1 (0.67) | LTA4HCYP11B1CYP11B2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001009129-A2 | 1H-PIRIDO[3, 4-B]INDOL-1-ONE DERIVATIVES | NOVUSPHARMA S.P.A. (IT) | 2001-02-08 | — | — | WO | disclosed |