Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7995089 | 0.86 | HTT (0.54) | HTTHTR1ALTB4RLTA4HHRH3 | |
| SCHEMBL7998680 | 0.80 | HTT (0.48) | HTTABCB1LTA4H | |
| SCHEMBL7992008 | 0.79 | HTT (0.47) | HTTHTR1ADRD2ABCB1LTA4H | |
| SCHEMBL7995324 | 0.78 | HTT (0.55) | HTTLTB4RLTA4HLMNACYP1A2 | |
| SCHEMBL7995327 | 0.77 | HTT (0.46) | HTTHTR1ADRD2HRH3LMNA | |
| SCHEMBL7981094 | 0.76 | HTT (0.45) | HTTLTA4HEPHX2LMNATSHR | |
| SCHEMBL7995311 | 0.72 | CALM1 (0.44) | HTTMAOBBCHE | |
| SCHEMBL7998689 | 0.71 | HTT (0.48) | HTTLTB4RMAOAMAOB | |
| SCHEMBL7993157 | 0.69 | HTT (0.49) | HTTHTR1ADRD2LMNACYP1A2 | |
| SCHEMBL10693246 | 0.65 | HTT (0.51) | HTTHTR1ALMNACYP1A2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001009129-A2 | 1H-PIRIDO[3, 4-B]INDOL-1-ONE DERIVATIVES | NOVUSPHARMA S.P.A. (IT) | 2001-02-08 | — | — | WO | disclosed |