SCHEMBL800305

SCHEMBL800305

CSCC[C@@H](NC(=O)OCC1c2ccccc2-c2ccccc21)C(=O)O

nearest known ligand 0.57

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
FDFT1 P37268 2/20 0.57
MDM4 O15151 2/20 0.55
TP53 P04637 2/20 0.55
MDM2 Q00987 5/20 0.54
CASP3 P42574 2/20 0.53
TLR2 O60603 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29768618 1.00 FDFT1 (0.57) FDFT1MDM4TP53MDM2CASP3
SCHEMBL29400804 1.00 FDFT1 (0.57) FDFT1MDM4TP53MDM2CASP3
SCHEMBL4600701 1.00 FDFT1 (0.57) FDFT1MDM4TP53MDM2CASP3
SCHEMBL29762010 1.00 FDFT1 (0.57) FDFT1MDM4TP53MDM2CASP3
SCHEMBL800035 1.00 FDFT1 (0.57) FDFT1MDM4TP53MDM2CASP3
SCHEMBL29362132 1.00 FDFT1 (0.57) FDFT1MDM4TP53MDM2CASP3
Sulfur Dioxide SCHEMBL29187399 0.98 FDFT1 (0.56) FDFT1MDM4TP53MDM2CASP3
SCHEMBL30437543 0.93 MDM2 (0.57) FDFT1MDM4TP53MDM2CASP3
SCHEMBL9062110 0.92 MDM4 (0.58) MDM4TP53MDM2CASP3TLR2
SCHEMBL9062116 0.92 MDM4 (0.58) MDM4TP53MDM2CASP3TLR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108728877-B Copper plating bath and copper plating film 上村工业株式会社 2022-07-05 CN disclosed
WO-2020252713-A1 MODIFIED HYDROPHOBIC AUXILIARY MATERIAL, PREPARATION METHOD THEREFOR AND USE THEREOF 浙江智达药业有限公司 2020-12-24 WO disclosed
US-9257576-B2 Amino acid generator and polysiloxane composition containing the same NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2016-02-09 US disclosed
US-20130313669-A1 AMINO ACID GENERATOR AND POLYSILOXANE COMPOSITION CONTAINING THE SAME NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2013-11-28 US disclosed
US-8410028-B2 Methods for synthesis of encoded libraries GLAXOSMITHKLINE LLC (US) 2013-04-02 US disclosed
US-8410028-B2 Methods for synthesis of encoded libraries GLAXOSMITHKLINE LLC (US) 2013-04-02 US disclosed
US-20120245040-A1 METHODS FOR SYNTHESIS OF ENCODED LIBRARIES GLAXOSMITHKLINE (US) 2012-09-27 US disclosed
US-20120245040-A1 METHODS FOR SYNTHESIS OF ENCODED LIBRARIES GLAXOSMITHKLINE (US) 2012-09-27 US disclosed
US-8269024-B2 Compounds and methods for modulating communication and virulence in quorum sensing bacteria WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2012-09-18 US disclosed
US-20120071329-A1 METHODS FOR IDENTIFYING COMPOUNDS OF INTEREST USING ENCODED LIBRARIES GLAXOSMITHKLINE LLC (US) 2012-03-22 US disclosed
US-20110073977-A1 AMINO ACID GENERATOR AND POLYSILOXANE COMPOSITION CONTAINING THE SAME NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2011-03-31 US disclosed
US-20100305182-A1 COMPOUNDS AND METHODS FOR MODULATING COMMUNICATION AND VIRULENCE IN QUORUM SENSING BACTERIA BLACKWELL HELEN E 2010-12-02 US disclosed
WO-2010116173-A1 DEPSIPEPTIDES AND THEIR THERAPEUTIC USE KARUS THERAPEUTICS LIMITED (GB) 2010-10-14 WO disclosed
US-20090062147-A1 Methods for synthesis of encoded libraries PRAECIS PHARMACEUTICALS INCORPORATED (US) 2009-03-05 US disclosed
CN-101243045-A New 2-azetidinone derivatives for the treatment of hyperlipidaemic diseases ASTRAZENECA AB (SE) 2008-08-13 CN disclosed
CN-101228123-A Novel 2-azetidinone derivatives and their use as cholesterol absorption inhibitors for the treatment of hyperlipidaemia ASTRAZENECA AB (SE) 2008-07-23 CN disclosed
US-20070224607-A1 Methods for identifying compounds of interest using encoded libraries PRAECIS PHARMACEUTICALS INCORPORATED (US) 2007-09-27 US disclosed
US-20070224607-A1 Methods for identifying compounds of interest using encoded libraries PRAECIS PHARMACEUTICALS INCORPORATED (US) 2007-09-27 US disclosed
US-20070042401-A1 Methods for synthesis of encoded libraries PRAECIS PHARMACEUTICALS, INC. (US) 2007-02-22 US disclosed
US-20070042401-A1 Methods for synthesis of encoded libraries PRAECIS PHARMACEUTICALS, INC. (US) 2007-02-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100305182-A1 COMPOUNDS AND METHODS FOR MODULATING COMMUNICATION AND VIRULENCE IN QUORUM SENSING BACTERIA AHCYL1, BPHL, AIP FDFT1 180/4885MDM4 974/4885TP53 2008/4885
US-20120245040-A1 METHODS FOR SYNTHESIS OF ENCODED LIBRARIES RNGTT, DTYMK, DUT FDFT1 34/4885MDM4 1148/4885TP53 2440/4885
US-20110073977-A1 AMINO ACID GENERATOR AND POLYSILOXANE COMPOSITION CONTAINING THE SAME DAO, BCAT1, BCAT2 FDFT1 360/4885MDM4 1211/4885TP53 1965/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.