Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8025466 | 0.86 | OPRM1 (0.46) | OPRM1OPRK1OPRL1HSD17B3HTR1A | |
| SCHEMBL8025493 | 0.81 | NPSR1 (0.47) | NPSR1KCNH2OPRM1OPRK1CHRM4 | |
| SCHEMBL8019199 | 0.75 | HTR1A (0.40) | OPRM1OPRK1OPRL1HSD17B3HTR1A | |
| SCHEMBL8022963 | 0.74 | OPRM1 (0.40) | OPRM1OPRK1OPRL1CHRM1HSD17B3 | |
| SCHEMBL8020392 | 0.74 | ALDH1A1 (0.42) | OPRM1OPRK1OPRL1HSD17B3HTR1A | |
| SCHEMBL8018517 | 0.74 | GPR119 (0.46) | HSD17B3BCHE | |
| SCHEMBL8021216 | 0.72 | DRD2 (0.41) | OPRM1OPRK1OPRL1HSD17B3HTR1A | |
| SCHEMBL8018967 | 0.71 | KCNH2 (0.45) | KCNH2OPRM1OPRK1CHRM4OPRL1 | |
| SCHEMBL8020388 | 0.70 | HTR1A (0.43) | KCNH2CHRM4CHRM1HSD17B3BCHE | |
| SCHEMBL8025512 | 0.70 | OPRL1 (0.60) | OPRM1OPRK1OPRL1DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6063779-A | CARDIOVASCULAR DISORDERS | MEIJI SEIKA KAISHA, LTD. (JP) | 2000-05-16 | — | — | US | disclosed |
| EP-0878475-A2 | 5-(4-Piperidinyl)dibenzothiazepine derivatives and 5-(4-piperidinyl)dibenzoxazepine derivatives, and antiarrhythmic agents | Meiji Seika Kaisha, Ltd. (JP) | 1998-11-18 | — | — | EP | disclosed |