Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | HRH2 | P25021 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR1E | P28566 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8020392 | 0.77 | ALDH1A1 (0.42) | HTR1ACHRM5ADRA2ADRD2ADRA2B | |
| SCHEMBL8025466 | 0.74 | OPRM1 (0.46) | HTR1ACHRM5ADRA2ADRD2ADRA2B | |
| SCHEMBL8018517 | 0.72 | GPR119 (0.46) | HSD17B3BCHE | |
| SCHEMBL8025493 | 0.72 | NPSR1 (0.47) | HTR1ACHRM5ADRA2ADRD2ADRA2B | |
| SCHEMBL8025494 | 0.70 | NPSR1 (0.43) | HTR1ACHRM5ADRA2ADRD2ADRA2B | |
| SCHEMBL8018967 | 0.70 | KCNH2 (0.45) | HTR1ACHRM5ADRA2ADRD2ADRA2B | |
| SCHEMBL8019134 | 0.69 | HTR2C (0.46) | HTR1ACHRM5ADRA2ADRD2ADRA2B | |
| SCHEMBL8025512 | 0.68 | OPRL1 (0.60) | DRD2DRD4HTR2AHTR2CDRD3 | |
| SCHEMBL8021216 | 0.68 | DRD2 (0.41) | HTR1ACHRM5ADRA2ADRD2ADRA2B | |
| SCHEMBL17933755 | 0.66 | MAOA (0.57) | HTR1ACHRM5ADRA2ADRD2ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6063779-A | CARDIOVASCULAR DISORDERS | MEIJI SEIKA KAISHA, LTD. (JP) | 2000-05-16 | — | — | US | disclosed |
| EP-0878475-A2 | 5-(4-Piperidinyl)dibenzothiazepine derivatives and 5-(4-piperidinyl)dibenzoxazepine derivatives, and antiarrhythmic agents | Meiji Seika Kaisha, Ltd. (JP) | 1998-11-18 | — | — | EP | disclosed |