Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | TYMP | P19971 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048034 | 0.83 | KIF11 (0.49) | CTSS | |
| SCHEMBL8043935 | 0.82 | RXRA (0.33) | IKBKB | |
| SCHEMBL8047497 | 0.79 | KIF11 (0.45) | NOTUMTP53MAOB | |
| SCHEMBL8047366 | 0.77 | TAAR1 (0.40) | NOTUMIDO1KDM4E | |
| SCHEMBL8043481 | 0.75 | CES2 (0.38) | TSHRMAPK1 | |
| SCHEMBL8042855 | 0.74 | ALDH1A1 (0.45) | IDO1TP53KDM4EHSD17B10TSHR | |
| SCHEMBL29678302 | 0.73 | TSHR (0.58) | CTSSNOTUMIDO1SCN2ATSHR | |
| SCHEMBL1263144 | 0.73 | TSHR (0.58) | CTSSNOTUMIDO1SCN2ATSHR | |
| Ammonia Solution, Strong SCHEMBL20472961 | 0.71 | MAOB (0.56) | CTSSNOTUMIDO1SCN2ATSHR | |
| SCHEMBL8042676 | 0.69 | HSD11B1 (0.42) | NOTUMHSD17B10TSHRMAPK1KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |