Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.33 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042454 | 0.83 | KCNA5 (0.42) | KCNA5MAPTRXFP1TP53CYP3A4 | |
| SCHEMBL6970855 | 0.79 | KCNA5 (0.53) | KCNA5MAPTRXFP1TP53NPC1 | |
| SCHEMBL6970836 | 0.76 | PKM (0.40) | MAPTUSP2CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6967437 | 0.71 | KMT2A (0.43) | MAPTGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL6975974 | 0.71 | AKR1C3 (0.48) | MAPTTP53CYP1A2CYP2C9RAB9A | |
| SCHEMBL7080877 | 0.71 | ALDH1A1 (0.46) | KCNA5MAPTRXFP1TP53SMN1; SMN2 | |
| SCHEMBL6966615 | 0.69 | KMT2A (0.43) | MAPTRXFP1CYP3A4MEN1KMT2A | |
| SCHEMBL6967275 | 0.68 | HTR6 (0.42) | KCNA5MAPTRXFP1TP53CYP3A4 | |
| SCHEMBL6965033 | 0.68 | AKR1C3 (0.44) | MAPTCYP1A2CYP2C9GAARAB9A | |
| SCHEMBL6963364 | 0.68 | MEN1 (0.54) | MAPTTP53USP2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166023-A | 1,5- and 3-O-substituted 1H-indazoles having anti-asthmatic, anti-allergic, anti-inflammatory, immunomodulating and neuroprotective action, process for their preparation and their use as medicaments | ARZNEIMITTELWERK DRESDEN GMBH (DE) | 2000-12-26 | — | — | US | disclosed |