Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045945 | 0.87 | RAB9A (0.46) | DCUN1D1PDPK1MGAMGAASI | |
| SCHEMBL8033274 | 0.80 | FBP1 (0.41) | DCUN1D1SMN1; SMN2KMT2AMEN1RAB9A | |
| SCHEMBL8048789 | 0.80 | HTR1A (0.45) | GAASMN1; SMN2KMT2AMEN1TSHR | |
| SCHEMBL8042050 | 0.79 | LMNA (0.42) | DCUN1D1GAASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL8044714 | 0.78 | RAB9A (0.34) | SMN1; SMN2KMT2AMEN1TSHRUSP2 | |
| SCHEMBL8044818 | 0.78 | RAB9A (0.41) | DCUN1D1SMN1; SMN2KMT2AMEN1TSHR | |
| SCHEMBL8050943 | 0.77 | FBP1 (0.42) | DCUN1D1SMN1; SMN2LMNAFBP1PDK1 | |
| SCHEMBL8050904 | 0.76 | ALDH1A1 (0.33) | GAASMN1; SMN2KMT2AMEN1TSHR | |
| SCHEMBL8046628 | 0.75 | AR (0.40) | MGAMGAASIMGAM2SMN1; SMN2 | |
| SCHEMBL8043417 | 0.75 | HDAC6 (0.36) | SMN1; SMN2USP2RAB9ANPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |