Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM5C | P41229 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033057 | 0.89 | RAB9A (0.44) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8049983 | 0.84 | RXRA (0.39) | RXRARXRBRXRGCYP1A2CYP2C9 | |
| SCHEMBL8044714 | 0.83 | RAB9A (0.34) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8044846 | 0.82 | RAB9A (0.42) | RXRARXRBRXRGRAB9ANPC1 | |
| SCHEMBL8047827 | 0.81 | NPC1 (0.41) | HDAC6HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8046142 | 0.81 | RXRA (0.38) | RXRARXRBRXRG | |
| SCHEMBL8045389 | 0.81 | RXRA (0.40) | RXRARXRBRXRGRAB9AL3MBTL1 | |
| SCHEMBL8042797 | 0.81 | MAPK8 (0.43) | RAB9ANPC1 | |
| SCHEMBL8032788 | 0.81 | PTGS2 (0.33) | KDM4ECYP1A2CYP2C9CYP2C19L3MBTL1 | |
| SCHEMBL8050397 | 0.78 | ALDH1A1 (0.40) | RXRARXRBRXRGKDM4EKDM6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |