Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.36 |
| ▸ | RAB9A | P51151 | 6/20 | 0.36 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP7 | Q93009 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044846 | 0.93 | RAB9A (0.42) | RXRARXRBRXRGHCAR2SMN1; SMN2 | |
| SCHEMBL8045389 | 0.90 | RXRA (0.40) | RXRARXRBRXRGHCAR2SMN1; SMN2 | |
| SCHEMBL8046142 | 0.85 | RXRA (0.38) | RXRARXRBRXRGHCAR2RECQL | |
| SCHEMBL8043417 | 0.84 | HDAC6 (0.36) | RXRARXRBRXRGCYP1A2CYP2C9 | |
| SCHEMBL8043447 | 0.83 | RXRA (0.43) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8033057 | 0.81 | RAB9A (0.44) | RXRARXRBRXRGSMN1; SMN2RAB9A | |
| SCHEMBL8042849 | 0.80 | ALDH1A1 (0.33) | CYP1A2CYP2C19SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL8034002 | 0.78 | LOXL2 (0.32) | RECQL | |
| SCHEMBL8043545 | 0.78 | RXRA (0.40) | RXRARXRBRXRGHCAR2USP7 | |
| SCHEMBL8050237 | 0.78 | RXRA (0.40) | RXRARXRBRXRGHCAR2USP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |