Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 2/20 | 0.33 |
| ▸ | RXRB | P28702 | 2/20 | 0.33 |
| ▸ | RXRG | P48443 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 2/20 | 0.30 |
| ▸ | CNR2 | P34972 | 2/20 | 0.30 |
| ▸ | QPCT | Q16769 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050331 | 0.81 | KIF11 (0.44) | S1PR1QPCTHDAC1HDAC2ALDH1A1 | |
| SCHEMBL14557095 | 0.80 | SNCA (0.37) | PTGS1PTGS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL969945 | 0.71 | PIK3CA (0.40) | PTGS1PTGS2ALDH1A1SMN1; SMN2 | |
| SCHEMBL14557099 | 0.71 | KDM4E (0.43) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL14338261 | 0.68 | CES2 (0.48) | IKBKBRXRARXRBRXRGCES2 | |
| SCHEMBL9482063 | 0.67 | RXRA (0.54) | IKBKBRXRARXRBRXRGCES2 | |
| SCHEMBL8050989 | 0.67 | ALDH1A1 (0.60) | PTGS2HDAC1HDAC2ALDH1A1SMN1; SMN2 | |
| SCHEMBL8048162 | 0.67 | P2RY1 (0.41) | F2RL3ALDH1A1SMN1; SMN2 | |
| SCHEMBL2753490 | 0.67 | IKBKB (0.36) | IKBKBF2RL3RXRARXRBRXRG | |
| SCHEMBL8046027 | 0.67 | CYP1A1 (0.46) | PTGS1PTGS2ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |