Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8071863 | 0.88 | LMNA (0.47) | ALDH1A1LMNAPOLBMAPTGFER | |
| SCHEMBL8071876 | 0.81 | MGLL (0.46) | ALDH1A1LMNAPOLBMAPTHTT | |
| SCHEMBL8071618 | 0.73 | DNMT1 (0.45) | ALDH1A1MAPTFLT3NPC1MAPK1 | |
| SCHEMBL8071641 | 0.73 | ALDH1A1 (0.47) | ALDH1A1LMNAPOLBMAPTNPSR1 | |
| SCHEMBL8061075 | 0.73 | EHMT2 (0.48) | ALDH1A1 | |
| SCHEMBL8076826 | 0.72 | ADRA1A (0.56) | — | |
| SCHEMBL8071878 | 0.72 | GPR119 (0.56) | ALDH1A1MAPTNPC1MAPK1HTT | |
| SCHEMBL18428484 | 0.70 | ALDH1A1 (0.59) | ALDH1A1MAPTNPSR1NAMPTNPC1 | |
| SCHEMBL8071621 | 0.69 | ABCG2 (0.48) | ALDH1A1LMNAMAPTNPSR1NPC1 | |
| SCHEMBL4243494 | 0.69 | ALDH1A1 (0.76) | ALDH1A1MAPTNPSR1NPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6156758-A | Antibacterial quinazoline compounds | ISIS PHARMACEUTICALS, INC. (US) | 2000-12-05 | — | — | US | disclosed |