Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.41 |
| ▸ | EDNRB | P24530 | 11/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | EDNRA | P25101 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084976 | 0.84 | EDNRB (0.50) | EDNRBEDNRAKDM4EALDH1A1HPGD | |
| SCHEMBL8082083 | 0.81 | TDP1 (0.42) | RAB9ASLC6A9EDNRBTDP1EDNRA | |
| SCHEMBL8072357 | 0.79 | ALOX5 (0.44) | RAB9ASLC6A9EDNRBTDP1EDNRA | |
| SCHEMBL8081905 | 0.78 | ALOX5 (0.45) | EDNRBEDNRAKDM4EALDH1A1HPGD | |
| SCHEMBL8085173 | 0.78 | ALDH1A1 (0.46) | EDNRBEDNRAKDM4EALDH1A1HPGD | |
| SCHEMBL8072411 | 0.77 | ALDH1A1 (0.42) | EDNRBEDNRAKDM4EALDH1A1HPGD | |
| SCHEMBL8072416 | 0.76 | ALDH1A1 (0.42) | EDNRBEDNRAKDM4EALDH1A1HPGD | |
| SCHEMBL8084890 | 0.74 | EDNRA (0.45) | EDNRBTDP1EDNRAKDM4EALDH1A1 | |
| SCHEMBL8081344 | 0.73 | PTGS2 (0.42) | EDNRBEDNRAKDM4EALDH1A1HPGD | |
| SCHEMBL2954233 | 0.72 | PRKCI (0.49) | RAB9AEDNRBKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |