Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 5/20 | 0.50 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.49 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.46 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.46 |
| ▸ | BMP1 | P13497 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8092409 | 0.89 | HSD11B1 (0.47) | RAB9A | |
| SCHEMBL8092470 | 0.88 | TAS2R14 (0.49) | TAS2R14LPAR1LPAR5ALOX5PTGES | |
| SCHEMBL8079204 | 0.87 | CNR2 (0.47) | TAS2R14ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL8086489 | 0.82 | ALDH1A1 (0.49) | ALDH1A1BMP1NPC1RAB9A | |
| SCHEMBL8079261 | 0.82 | HSD11B1 (0.45) | LPAR1 | |
| SCHEMBL8087753 | 0.80 | TAS2R14 (0.55) | TAS2R14LPAR1LPAR5ALOX5PTGES | |
| SCHEMBL8090675 | 0.77 | TAAR1 (0.43) | TAS2R14RAB9A | |
| SCHEMBL8087752 | 0.76 | CES2 (0.43) | ALOX5PTGESNPC1RAB9A | |
| SCHEMBL8087638 | 0.76 | TAS2R14 (0.50) | TAS2R14ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL8087708 | 0.76 | TRPM8 (0.45) | ALDH1A1MAPTRAB9ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047670-A1 | AMINOSULPHONYLBENZAMIDE DERIVATIVES AS MODULATORS OF THE ACTIVITY OF NEURONAL CALCIUM CHANNELS | ELI LILLY AND COMPANY LIMITED (GB) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999036398-A1 | AMINOSULPHONYLBENZAMIDE DERIVATIVES AS MODULATORS OF THE ACTIVITY OF NEURONAL CALCIUM CHANNELS | ELI LILLY AND COMPANY LIMITED (GB) | 1999-07-22 | — | — | WO | disclosed |