Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | CETP | P11597 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8087708 | 0.90 | TRPM8 (0.45) | TRPM8MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL8090715 | 0.84 | TAS2R14 (0.53) | MEN1KMT2ALMNAHSD11B1PTGES | |
| SCHEMBL8087753 | 0.81 | TAS2R14 (0.55) | HSD11B1PTGES | |
| SCHEMBL8087638 | 0.78 | TAS2R14 (0.50) | LMNASMN1; SMN2HSD11B1HDAC6RAB9A | |
| SCHEMBL8092409 | 0.76 | HSD11B1 (0.47) | SMN1; SMN2HSD11B1HDAC6RAB9A | |
| SCHEMBL8079261 | 0.74 | HSD11B1 (0.45) | MEN1KMT2ALMNAHSD11B1HDAC6 | |
| SCHEMBL8090718 | 0.73 | TAS2R14 (0.47) | SMN1; SMN2HSD11B1HDAC6RAB9AALDH1A1 | |
| SCHEMBL8087612 | 0.73 | LPAR1 (0.43) | MEN1KMT2ASMN1; SMN2HSD11B1ALDH1A1 | |
| SCHEMBL8086467 | 0.72 | TAS2R14 (0.46) | MEN1KMT2ASMN1; SMN2HSD11B1HDAC6 | |
| SCHEMBL8092470 | 0.72 | TAS2R14 (0.49) | PTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1047670-A1 | AMINOSULPHONYLBENZAMIDE DERIVATIVES AS MODULATORS OF THE ACTIVITY OF NEURONAL CALCIUM CHANNELS | ELI LILLY AND COMPANY LIMITED (GB) | 2000-11-02 | — | — | EP | disclosed |
| WO-1999036398-A1 | AMINOSULPHONYLBENZAMIDE DERIVATIVES AS MODULATORS OF THE ACTIVITY OF NEURONAL CALCIUM CHANNELS | ELI LILLY AND COMPANY LIMITED (GB) | 1999-07-22 | — | — | WO | disclosed |