Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.36 |
| ▸ | KIF11 | P52732 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CTPS1 | P17812 | 3/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8097966 | 0.91 | KIF11 (0.37) | NAMPTKIF11ALDH1A1IDO1TDO2 | |
| SCHEMBL8094619 | 0.90 | PIP4K2A (0.40) | NAMPTCYP2C9CTPS1PIK3CDPIK3CA | |
| SCHEMBL8083200 | 0.89 | ALDH1A1 (0.43) | NAMPTKIF11ALDH1A1IDO1TDO2 | |
| SCHEMBL8090868 | 0.85 | MTOR (0.38) | NAMPTKIF11ALDH1A1PIK3CDPIK3CA | |
| SCHEMBL8084982 | 0.85 | KIF11 (0.38) | NAMPTKIF11ALDH1A1IDO1TDO2 | |
| SCHEMBL8091293 | 0.84 | MAPT (0.42) | NAMPTKIF11ALDH1A1PIK3CAMTOR | |
| SCHEMBL8082685 | 0.82 | IDO1 (0.40) | ALDH1A1IDO1TDO2PIK3CAMTOR | |
| SCHEMBL8104712 | 0.82 | IDO1 (0.40) | NAMPTKIF11ALDH1A1IDO1TDO2 | |
| SCHEMBL8090834 | 0.82 | KIF11 (0.35) | KIF11ALDH1A1IDO1TDO2PIK3CD | |
| SCHEMBL8083416 | 0.81 | PIK3R1 (0.39) | NAMPTKIF11ALDH1A1IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |