Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10930335 | 0.86 | NOTUM (0.44) | NOTUMSMN1; SMN2PKMALDH1A1HSD17B10 | |
| SCHEMBL7828758 | 0.83 | SMN1; SMN2 (0.47) | NOTUMSMN1; SMN2PKMALDH1A1KDM4E | |
| SCHEMBL7828761 | 0.83 | SMN1; SMN2 (0.47) | NOTUMSMN1; SMN2PKMALDH1A1KDM4E | |
| SCHEMBL8092415 | 0.82 | BRD4 (0.39) | SMN1; SMN2ALDH1A1L3MBTL1HSD17B10LMNA | |
| SCHEMBL8099968 | 0.82 | MCHR1 (0.42) | SMN1; SMN2ALDH1A1L3MBTL1HSD17B10LMNA | |
| SCHEMBL8091499 | 0.81 | NLRP3 (0.40) | NOTUMSMN1; SMN2PKMALDH1A1KDM4E | |
| SCHEMBL6954890 | 0.81 | HTR1A (0.43) | NOTUMSMN1; SMN2ALDH1A1TDP1HTR1A | |
| SCHEMBL8092437 | 0.80 | ADRA2A (0.43) | HPGDADRA2ATSHRLMNA | |
| SCHEMBL8097781 | 0.79 | ADRA2A (0.43) | NOTUMSMN1; SMN2ALDH1A1KDM4ETDP1 | |
| SCHEMBL8097604 | 0.79 | ADRA2A (0.43) | NOTUMSMN1; SMN2ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1183907-C | Imidazoline compound, preparing process thereof and pharmaceutical composition contg. same | SERVIER LAB (FR) | 2005-01-12 | — | — | CN | disclosed |
| US-6127396-A | Imidazoline compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |
| US-4540705-A | Antidepressant imidazolines and related compounds | STERLING DRUG INC. (US) | 1985-09-10 | — | — | US | disclosed |
| EP-0125410-A2 | Imidazolines and related compounds and preparation thereof | STERLING DRUG INC. (US) | 1984-11-21 | — | — | EP | disclosed |