Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MC3R | P41968 | 2/20 | 0.33 |
| ▸ | MC1R | Q01726 | 2/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | FURIN | P09958 | 1/20 | 0.31 |
| ▸ | TGM2 | P21980 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.31 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.31 |
| ▸ | GRB2 | P62993 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8098063 | 0.90 | CES2 (0.37) | CES2MAPTHTTLMNAMC3R | |
| SCHEMBL8091511 | 0.87 | SMN1; SMN2 (0.40) | LMNANAMPTSMN1; SMN2ALDH1A1POLB | |
| SCHEMBL8090119 | 0.81 | CAPN1 (0.33) | LMNASMN1; SMN2KDM4EALDH1A1PKM | |
| SCHEMBL8091691 | 0.79 | ALDH1A1 (0.33) | TSHRALDH1A1 | |
| SCHEMBL8083619 | 0.78 | SMN1; SMN2 (0.42) | LMNASMN1; SMN2ALDH1A1POLB | |
| SCHEMBL8096021 | 0.71 | CYP1A2 (0.37) | CES2MAPTHTTLMNAMC3R | |
| SCHEMBL8090174 | 0.67 | F2 (0.39) | KDM4ECYP1A2 | |
| SCHEMBL8095300 | 0.67 | CYP3A4 (0.36) | TSHRALDH1A1CYP1A2 | |
| SCHEMBL8090189 | 0.66 | MMP8 (0.37) | KDM4ECYP1A2 | |
| SCHEMBL21171990 | 0.66 | HDAC1 (0.50) | MC3RMC1RMC4RCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0792883-B1 | Novel derivates of boronic acid, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-12-20 | — | — | EP | disclosed |
| EP-0792883-A1 | Novel derivates of boronic acid, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1997-09-03 | — | — | EP | disclosed |