Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 6/20 | 0.61 |
| ▸ | MMP8 | P22894 | 5/20 | 0.61 |
| ▸ | MMP13 | P45452 | 5/20 | 0.61 |
| ▸ | MMP1 | P03956 | 2/20 | 0.55 |
| ▸ | MMP7 | P09237 | 1/20 | 0.55 |
| ▸ | CASP1 | P29466 | 2/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8657587 | 0.87 | MMP8 (0.51) | MMP12MMP8MMP13MMP1MMP7 | |
| SCHEMBL4170793 | 0.84 | MMP12 (0.82) | MMP12MMP8MMP13MMP1MMP7 | |
| SCHEMBL8101293 | 0.80 | L3MBTL1 (0.49) | MMP12MMP8MMP13MMP1MMP7 | |
| SCHEMBL27373395 | 0.78 | HDAC3 (0.47) | MMP12MMP8MMP13MMP1MMP7 | |
| SCHEMBL8104304 | 0.77 | ALDH1A1 (0.44) | MMP12MMP8MMP13MMP1MMP7 | |
| SCHEMBL8653921 | 0.77 | MMP1 (0.40) | MMP12MMP8MMP13MMP1MMP7 | |
| SCHEMBL8095873 | 0.76 | MEN1 (0.45) | MMP12MMP8MMP13MMP1MMP7 | |
| SCHEMBL24486785 | 0.76 | CA2 (0.50) | L3MBTL1CA1CA2CA9GAA | |
| SCHEMBL8532428 | 0.76 | KEAP1 (0.50) | MMP12MMP13CA1CA2CA9 | |
| SCHEMBL5281032 | 0.76 | MMP8 (0.62) | MMP12MMP8MMP13MMP1MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080869-A | Benzothiazolone derivatives | ASTRA PHARMACEUTICALS LIMITED (GB) | 2000-06-27 | — | — | US | disclosed |
| EP-0850232-B1 | BENZOTHIAZOLONE DERIVATIVES | ASTRA PHARMA PROD (GB) | 2000-03-15 | — | — | EP | disclosed |
| US-6008365-A | ADRENORECEPTOR AGONISTS AND DOPAMINE DA2-RECEPTOR AGONISTS, USEFUL IN THE TREATMENT OF OBSTRUCTIVE AIRWAY DISEASES | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-12-28 | — | — | US | disclosed |
| US-5977384-A | Benzothiazolone derivatives | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-11-02 | — | — | US | disclosed |
| US-5973167-A | Intermediates for making benzothiazolone derivatives | ASTRA PHARMACEUTICALS LTD. (GB) | 1999-10-26 | — | — | US | disclosed |
| US-5846989-A | Benzothiazolone derivatives | ASTRA PHARMACEUTICALS LIMITED (GB) | 1998-12-08 | — | — | US | disclosed |