Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | DRD1 | P21728 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 2/20 | 0.40 |
| ▸ | PRNP | P04156 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8093559 | 0.96 | ALDH1A1 (0.43) | ALDH1A1LMNASMN1; SMN2KMT2ANPSR1 | |
| SCHEMBL8101320 | 0.91 | CYP2D6 (0.40) | ALDH1A1LMNASMN1; SMN2KMT2ANPSR1 | |
| SCHEMBL8101312 | 0.87 | HTR1A (0.39) | ALDH1A1LMNASMN1; SMN2KMT2ANPSR1 | |
| SCHEMBL8103441 | 0.85 | KDM4E (0.38) | ALDH1A1LMNASMN1; SMN2KMT2ANPSR1 | |
| SCHEMBL8101553 | 0.80 | GAA (0.38) | ALDH1A1LMNASMN1; SMN2KMT2ANPSR1 | |
| SCHEMBL8101460 | 0.76 | PKM (0.36) | ALDH1A1POLBMAPTCYP1A2TP53 | |
| SCHEMBL8107634 | 0.72 | PKM (0.37) | ALDH1A1LMNAKMT2ANPSR1POLB | |
| SCHEMBL8101317 | 0.70 | KDM4E (0.47) | ALDH1A1LMNASMN1; SMN2POLBMAPT | |
| SCHEMBL8101555 | 0.68 | CYP2D6 (0.54) | ALDH1A1LMNASMN1; SMN2KMT2ANPSR1 | |
| SCHEMBL8103445 | 0.68 | CYP2D6 (0.44) | ALDH1A1LMNASMN1; SMN2KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127369-A | 5,10-dihydrodipyrido[2,3-b:2,3-e]pyrazin and 5,10-dihydrodipyrido[2,3-b:3,2-e]pyrazin compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |