Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8101460 | 0.96 | PKM (0.36) | PKMPOLBCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8101553 | 0.90 | GAA (0.38) | CYP1A2CYP2C9CYP2C19ALDH1A1MAPT | |
| SCHEMBL8101312 | 0.87 | HTR1A (0.39) | POLBCYP1A2CYP2C19ALDH1A1MAPT | |
| SCHEMBL8103441 | 0.86 | KDM4E (0.38) | CYP1A2CYP2C9CYP2C19ALDH1A1MAPT | |
| SCHEMBL8101320 | 0.84 | CYP2D6 (0.40) | POLBCYP1A2CYP2C19ALDH1A1MAPT | |
| SCHEMBL8103457 | 0.81 | ALDH1A1 (0.44) | POLBCYP1A2ALDH1A1MAPTMAPK1 | |
| SCHEMBL8103233 | 0.78 | KDM4E (0.40) | POLBCYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL8103437 | 0.78 | ALDH1A1 (0.39) | CYP1A2ALDH1A1MAPTMAPK1TP53 | |
| SCHEMBL8101881 | 0.77 | ALDH1A1 (0.43) | POLBCYP1A2ALDH1A1MAPTMAPK1 | |
| SCHEMBL8103439 | 0.77 | KDM4E (0.40) | POLBCYP1A2CYP2C9CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127369-A | 5,10-dihydrodipyrido[2,3-b:2,3-e]pyrazin and 5,10-dihydrodipyrido[2,3-b:3,2-e]pyrazin compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |