SCHEMBL8115803

SCHEMBL8115803

O=c1cc[nH]n1-c1nccs1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC11A2 P49281 1/20 0.48
KDM4C Q9H3R0 2/20 0.42
KDM2B Q8NHM5 1/20 0.42
TDP1 Q9NUW8 3/20 0.40
ALDH1A1 P00352 6/20 0.40
KDM4E B2RXH2 5/20 0.40
GAA P10253 2/20 0.40
HSD17B10 Q99714 2/20 0.40
MAPT P10636 2/20 0.40
G6PD P11413 1/20 0.40
PKM P14618 1/20 0.40
MPI P34949 1/20 0.40
EP300 Q09472 1/20 0.40
KAT2A Q92830 1/20 0.40
KAT2B Q92831 1/20 0.40
POLB P06746 2/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
APEX1 P27695 1/20 0.37
RECQL P46063 1/20 0.37
AKR1C3 P42330 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL409136 0.72 TDP1 (0.38) SLC11A2KDM4CTDP1ALDH1A1KDM4E
SCHEMBL1267187 0.69 ALKBH5 (0.47) SLC11A2KDM4CAKR1C3
SCHEMBL25430620 0.68 SMN1; SMN2 (0.43) SLC11A2KDM4CTDP1ALDH1A1KDM4E
SCHEMBL7601190 0.66 CHEK1 (0.58) SLC11A2KDM4CKDM2BKDM4EGAA
SCHEMBL10749347 0.65 GABRA1 (0.56)
SCHEMBL4078464 0.65 SLC11A2 (0.45) SLC11A2TDP1ALDH1A1KDM4EGAA
SCHEMBL4789303 0.64 ALDH1A1 (0.43) SLC11A2TDP1ALDH1A1KDM4EGAA
SCHEMBL5579491 0.64 LMNA (0.53) SLC11A2TDP1ALDH1A1KDM4EGAA
SCHEMBL409135 0.63 CRBN (0.44) SLC11A2KDM4CTDP1ALDH1A1KDM4E
SCHEMBL16794591 0.62 LMNA (0.54) SLC11A2KDM4CTDP1ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0752989-B1 THIAZOLYLPYRAZOLINONES AND THEIR USE FOR PROTECTING TECHNICAL MATERIALS BAYER AG (DE) 2000-07-19 EP claimed
US-5703103-A MICROBIOCIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-12-30 US claimed
EP-3799871-B1 PYRAZOL-3-ONES THAT ACTIVATE PRO-APOTOTIC BAX DANA FARBER CANCER INST INC (US) 2024-02-28 EP disclosed
WO-2023141262-A1 BAX ACTIVATORS AND USE THEREOF IPSEN PHARMA S.A.S. (FR) 2023-07-27 WO disclosed
US-20220298154-A1 PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX DANA-FARBER CANCER INSTITUTE, INC. 2022-09-22 US disclosed
US-11358960-B2 Pyrazol-3-ones that activate pro-apoptotic BAX DANA-FARBER CANCER INSTITUTE, INC. (US) 2022-06-14 US disclosed
EP-3799871-A2 PYRAZOL-3-ONES THAT ACTIVATE PRO-APOTOTIC BAX Dana Farber Cancer Institute, Inc. (US) 2021-04-07 EP disclosed
US-20210032234-A1 PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX DANA-FARBER CANCER INSTITUTE, INC. 2021-02-04 US disclosed
US-10844053-B2 Pyrazol-3-ones that activate pro-apoptotic BAX DANA-FARBER CANCER INSTITUTE, INC. (US) 2020-11-24 US disclosed
US-20190315730-A1 PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX DANA-FARBER CANCER INSTITUTE, INC. 2019-10-17 US disclosed
US-10351554-B2 Pyrazol-3-ones that activate pro-apoptotic BAX DANA-FARBER CANCER INSTITUTE, INC. (US) 2019-07-16 US disclosed
EP-0752989-B1 THIAZOLYLPYRAZOLINONES AND THEIR USE FOR PROTECTING TECHNICAL MATERIALS BAYER AG (DE) 2000-07-19 EP disclosed
EP-0752989-B1 THIAZOLYLPYRAZOLINONES AND THEIR USE FOR PROTECTING TECHNICAL MATERIALS BAYER AG (DE) 2000-07-19 EP disclosed
US-5703103-A MICROBIOCIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-12-30 US disclosed
US-5703103-A MICROBIOCIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-12-30 US disclosed
US-5703103-A MICROBIOCIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-12-30 US disclosed
EP-0752989-A1 THIAZOLYLPYRAZOLINONES AND THEIR USE FOR PROTECTING TECHNICAL MATERIALS BAYER AG (DE) 1997-01-15 EP disclosed
EP-0752989-A1 THIAZOLYLPYRAZOLINONES AND THEIR USE FOR PROTECTING TECHNICAL MATERIALS BAYER AG (DE) 1997-01-15 EP disclosed
WO-1995026962-A1 THIAZOLYLPYRAZOLINONES AND THEIR USE FOR PROTECTING TECHNICAL MATERIALS BAYER AKTIENGESELLSCHAFT (DE) 1995-10-12 WO disclosed
WO-1995026962-A1 THIAZOLYLPYRAZOLINONES AND THEIR USE FOR PROTECTING TECHNICAL MATERIALS BAYER AKTIENGESELLSCHAFT (DE) 1995-10-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210032234-A1 PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX BAX, BAD, CASP3 SLC11A2 2622/4885KDM4C 4507/4885KDM2B 4675/4885
US-10844053-B2 Pyrazol-3-ones that activate pro-apoptotic BAX BAX, BAD, CASP3 SLC11A2 2622/4885KDM4C 4507/4885KDM2B 4675/4885
US-20220298154-A1 PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX BAX, BAD, CASP3 SLC11A2 2622/4885KDM4C 4507/4885KDM2B 4675/4885
US-11358960-B2 Pyrazol-3-ones that activate pro-apoptotic BAX BAX, BAD, CASP3 SLC11A2 2622/4885KDM4C 4507/4885KDM2B 4675/4885
US-20190315730-A1 PYRAZOL-3-ONES THAT ACTIVATE PRO-APOPTOTIC BAX BAX, BAD, CASP3 SLC11A2 2622/4885KDM4C 4507/4885KDM2B 4675/4885
US-10351554-B2 Pyrazol-3-ones that activate pro-apoptotic BAX BAX, BAD, CASP3 SLC11A2 2622/4885KDM4C 4507/4885KDM2B 4675/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.