Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 8/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 5/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.45 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.43 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1907786 | 0.92 | RXRA (0.53) | PTGER1CYP1A2CCR5RXRAUSP28 | |
| SCHEMBL7662467 | 0.90 | CCR5 (0.45) | PTGER1CYP1A2CCR5RXRAUSP28 | |
| SCHEMBL8810232 | 0.89 | PARP15 (0.49) | PTGER1RXRAALDH1A1RAB9ALMNA | |
| SCHEMBL8703967 | 0.87 | CCR5 (0.48) | PTGER1CYP1A2CCR5RXRA | |
| SCHEMBL8162566 | 0.87 | CCR5 (0.45) | PTGER1CYP1A2CCR5RXRAHTT | |
| SCHEMBL8161075 | 0.87 | LMNA (0.48) | PTGER1CYP1A2CCR5USP28USP25 | |
| SCHEMBL8167158 | 0.86 | RAB9A (0.44) | PTGER1CYP1A2CCR5RXRAUSP28 | |
| SCHEMBL8155611 | 0.85 | PTGER1 (0.46) | PTGER1CYP1A2CCR5USP28USP25 | |
| SCHEMBL8701112 | 0.85 | CCR5 (0.46) | PTGER1CYP1A2CCR5RXRAALDH1A1 | |
| SCHEMBL8162210 | 0.85 | ALDH1A1 (0.45) | PTGER1CYP1A2CCR5RXRAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1085663-C | Aromatic amino ethers as analgesic agents | ZENECA LTD (GB) | 2002-05-29 | — | — | CN | disclosed |
| CN-1286254-A | Aromatic amino ethers as analgesic agents | ZENECA LTD (GB) | 2001-03-07 | — | — | CN | disclosed |
| EP-0773930-B1 | AROMATIC AMINO ETHERS AS PAIN RELIEVING AGENTS | ZENECA LTD (GB) | 2000-10-11 | — | — | EP | disclosed |
| US-5843942-A | Aromatic amino ethers as pain relieving agents | ZENECA LIMITED (GB) | 1998-12-01 | — | — | US | disclosed |
| CN-1154106-A | Aromatic amino ethers as analgesic agents | ZENECA LTD (GB) | 1997-07-09 | — | — | CN | disclosed |
| EP-0773930-A1 | AROMATIC AMINO ETHERS AS PAIN RELIEVING AGENTS | ZENECA LIMITED (GB) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996003380-A1 | AROMATIC AMINO ETHERS AS PAIN RELIEVING AGENTS | ZENECA LIMITED (GB) | 1996-02-08 | — | — | WO | disclosed |