Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8167206 | 0.86 | PKM (0.51) | SMN1; SMN2CA12CA1CA2CA5A | |
| SCHEMBL741235 | 0.83 | ALPL (0.51) | TRPV4SMN1; SMN2CA2KDM4EGLA | |
| SCHEMBL24503566 | 0.79 | TRPV4 (0.45) | TRPV4SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL9724436 | 0.78 | CA5A (0.61) | TRPV4CA5AL3MBTL1TSHRGAA | |
| SCHEMBL4660848 | 0.78 | CA5A (0.47) | TRPV4SMN1; SMN2CA5AHTTCYP3A4 | |
| SCHEMBL30997420 | 0.78 | CA5A (0.47) | TRPV4SMN1; SMN2CA5AHTTCYP3A4 | |
| SCHEMBL2915192 | 0.77 | GAA (0.47) | TRPV4CA5ACYP1A2CYP3A4POLB | |
| SCHEMBL1332082 | 0.77 | ATM (0.66) | SMN1; SMN2CA2ATMKDM4ECYP1A2 | |
| SCHEMBL9404006 | 0.76 | ALOX5 (0.39) | TRPV4SMN1; SMN2CA1CA2CA9 | |
| SCHEMBL8172768 | 0.76 | MAPT (0.52) | SMN1; SMN2CA12CA1CA2CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6090825-A | Oxazole derivatives as antagonists of alpha 1C andrenergic receptors | GLAXO WELLCOME INC. (US) | 2000-07-18 | — | — | US | disclosed |
| EP-0793658-A1 | OXAZOLE DERIVATIVES AS ANTAGONISTS OF ALPHA-1C ADRENERGIC RECEPTORS | GLAXO WELLCOME INC. (US) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016049-A1 | OXAZOLE DERIVATIVES AS ANTAGONISTS OF α-1C ADRENERGIC RECEPTORS | GLAXO WELLCOME INC. (US) | 1996-05-30 | — | — | WO | disclosed |