Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7414197 | 0.82 | SIGMAR1 (0.50) | KMT2AMEN1HDAC8HDAC6EPHX2 | |
| SCHEMBL7412504 | 0.81 | GAA (0.57) | KMT2AMEN1HDAC8HDAC6EPHX2 | |
| SCHEMBL8066357 | 0.79 | GAA (0.59) | KMT2AMEN1HDAC8HDAC6EPHX2 | |
| SCHEMBL8060133 | 0.78 | L3MBTL1 (0.58) | POLBALDH1A1LMNAL3MBTL1 | |
| SCHEMBL8403770 | 0.78 | L3MBTL1 (0.67) | KMT2AMEN1EPHX2SIGMAR1POLB | |
| SCHEMBL7412108 | 0.77 | POLB (0.55) | KMT2AMEN1HDAC8HDAC6EPHX2 | |
| SCHEMBL7414475 | 0.76 | KDM4E (0.60) | KMT2AMEN1SIGMAR1MAPTPKM | |
| SCHEMBL699925 | 0.75 | MEN1 (0.71) | KMT2AMEN1HDAC8HDAC6EPHX2 | |
| SCHEMBL8329590 | 0.75 | FAAH (0.49) | KMT2AMEN1HDAC8HDAC6SIGMAR1 | |
| SCHEMBL11377543 | 0.74 | DPP4 (0.43) | KMT2AMEN1HDAC8HDAC6EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6117840-A | INHIBITS BINDING BETWEEN VLA-4 RECEPTOR EXPRESSED ON INFLAMMATORY LEUKOCYTES AND FIBRONECTIN CS-1 PEPTIDE EXPRESSED ON ENDOTHELIAL CELLS THAT ARE INVOLVED IN IMMUNOINFLAMMATORY DISEASE STATES | CYTEL CORPORATION (US) | 2000-09-12 | — | — | US | disclosed |
| US-5770573-A | CS-1 peptidomimetics, compositions and methods of using the same | CYTEL CORPORATION (US) | 1998-06-23 | — | — | US | disclosed |
| US-5688913-A | OLIGOPEPTIDES AS ANTIINFLAMMATORY AGENTS | CYTEL CORPORATION (US) | 1997-11-18 | — | — | US | disclosed |