SCHEMBL8201728

SCHEMBL8201728

CCCCC(C=O)(CC)C(C)Sc1ccc(OC)cc1.O=c1c2ccccc12

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX4 Q99571 1/20 0.34
PPARG P37231 5/20 0.33
PPARA Q07869 5/20 0.33
ALOX5 P09917 4/20 0.33
ALDH1A1 P00352 5/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
SENP6 Q9GZR1 1/20 0.32
PTGES O14684 2/20 0.31
HPGD P15428 2/20 0.31
KDM4E B2RXH2 2/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
CNR2 P34972 1/20 0.31
CYP2C9 P11712 1/20 0.31
MAPT P10636 2/20 0.31
LMNA P02545 1/20 0.31
HTT P42858 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31
NPC1 O15118 2/20 0.30
RAB9A P51151 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6198806 0.78 P2RX4 (0.35) P2RX4ALDH1A1MEN1KMT2ASENP6
SCHEMBL8892569 0.67 L3MBTL1 (0.33) CNR2CYP2C9LMNAHTTL3MBTL1
SCHEMBL8202225 0.63 CNR1 (0.37) PPARGALOX5ALDH1A1PTGESCNR2
SCHEMBL4192430 0.60 CA1 (0.52) ALDH1A1MEN1KMT2AKDM4ESMN1; SMN2
SCHEMBL9618135 0.60 MMP13 (0.38) PPARGPPARAALOX5ALDH1A1MEN1
SCHEMBL9621498 0.60 ALDH1A1 (0.42) ALDH1A1MEN1KMT2AHPGDSMN1; SMN2
SCHEMBL7706703 0.60 KIF11 (0.73) ALDH1A1MEN1KMT2ASMN1; SMN2LMNA
SCHEMBL10877618 0.60 KIF11 (0.73) ALDH1A1MEN1KMT2ASMN1; SMN2LMNA
SCHEMBL28013250 0.59 MTNR1A (0.40) ALDH1A1MEN1KMT2AKDM4ESMN1; SMN2
SCHEMBL6930527 0.59 PPARG (0.67) PPARGPPARAALOX5PTGES

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0971744-A2 COMBINATION THERAPY EMPLOYING ILEAL BILE ACID TRANSPORT INHIBITING BENZOTHIEPINES AND HMG Co-A REDUCTASE INHIBITORS G.D. SEARLE & CO. (US) 2000-01-19 EP disclosed
WO-1998040375-A2 COMBINATION OF ILEAL BILE ACID TRANSPORT INHIBITING BENZOTHIEPINES AND HMG Co-A REDUCTASE INHIBITORS G.D. SEARLE & CO. (US) 1998-09-17 WO disclosed
WO-1997033882-A1 NOVEL BENZOTHIEPINES HAVING ACTIVITY AS INHIBITORS OF ILEAL BILE ACID TRANSPORT AND TAUROCHOLATE UPTAKE G.D. SEARLE AND CO. (US) 1997-09-18 WO disclosed