Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 8/20 | 0.60 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.49 |
| ▸ | FAAH | O00519 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.47 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8061292 | 0.85 | LTA4H (0.65) | LTA4H | |
| SCHEMBL8046154 | 0.78 | L3MBTL1 (0.49) | LTA4HFAAHACHELMNAMAPK1 | |
| SCHEMBL5004504 | 0.77 | ALOX15 (0.70) | LTA4HLMNAMAPK1CASP3SENP7 | |
| SCHEMBL7136224 | 0.75 | LTA4H (1.00) | LTA4HS1PR1S1PR3S1PR5FFAR1 | |
| SCHEMBL7135460 | 0.74 | LTA4H (1.00) | LTA4HS1PR1S1PR3L3MBTL1S1PR5 | |
| SCHEMBL8211659 | 0.73 | LTA4H (0.60) | LTA4HS1PR1S1PR3S1PR5FFAR1 | |
| SCHEMBL9271748 | 0.73 | KMT2A (0.82) | FAAHACHELMNAL3MBTL1HPGD | |
| SCHEMBL11528650 | 0.71 | LMNA (0.59) | LTA4HLMNAMAPK1CASP3SENP7 | |
| SCHEMBL8046227 | 0.71 | WDR5 (0.58) | LTA4HLMNAMAPK1CASP3SENP7 | |
| SCHEMBL9787068 | 0.70 | LMNA (0.80) | LTA4HLMNAMAPK1CASP3SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971909-A1 | LTA 4? HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 2000-01-19 | — | — | EP | claimed |
| WO-1998040370-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-09-17 | — | — | WO | claimed |
| EP-0971909-A1 | LTA 4? HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998040370-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-09-17 | — | — | WO | disclosed |