Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASAH1 | Q13510 | 2/20 | 0.57 |
| ▸ | MGLL | Q99685 | 1/20 | 0.53 |
| ▸ | MGAM | O43451 | 6/20 | 0.49 |
| ▸ | AMY1A | P0DUB6 | 6/20 | 0.49 |
| ▸ | GAA | P10253 | 6/20 | 0.49 |
| ▸ | SI | P14410 | 6/20 | 0.49 |
| ▸ | MGAM2 | Q2M2H8 | 6/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.49 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.46 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.46 |
| ▸ | F12 | P00748 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8221504 | 0.89 | ASAH1 (0.60) | ASAH1MGLLMGAMAMY1AGAA | |
| SCHEMBL8221643 | 0.84 | ASAH1 (0.64) | ASAH1MGLLMGAMAMY1AGAA | |
| SCHEMBL20150832 | 0.80 | ASAH1 (0.71) | ASAH1MGLLMGAMAMY1AGAA | |
| SCHEMBL13253160 | 0.80 | ASAH1 (0.58) | ASAH1MGLLMGAMAMY1AGAA | |
| SCHEMBL9419551 | 0.77 | MGAM (0.58) | ASAH1MGLLMGAMAMY1AGAA | |
| SCHEMBL427517 | 0.77 | ASAH1 (0.70) | ASAH1MGLLMGAMAMY1AGAA | |
| SCHEMBL14632207 | 0.76 | ASAH1 (0.77) | ASAH1MGLLMGAMAMY1AGAA | |
| SCHEMBL443991 | 0.75 | GAA (0.64) | MGAMAMY1AGAASIMGAM2 | |
| SCHEMBL2968841 | 0.75 | DGAT1 (0.61) | MGAMAMY1AGAASIMGAM2 | |
| SCHEMBL12593813 | 0.75 | ASAH1 (0.83) | ASAH1MGLLMGAMAMY1AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039467-B2 | Compounds for the treatment of inflammatory disorders | SCHERING CORPORATION (US) | 2011-10-18 | — | — | US | disclosed |
| US-20100145048-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION | 2010-06-10 | — | — | US | disclosed |
| US-7652020-B2 | novel hydantoin derivatives to inhibit matrix metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs) and/or tumor necrosis factor alpha converting enzyme (TACE) and in so doing prevent the release of tumor necrosis factor alpha (TNF- alpha ); autoimmune diseases; side effect reduction | SCHERING CORPORATION (US) | 2010-01-26 | — | — | US | disclosed |
| US-7638513-B2 | Compounds for the treatment of inflammatory disorders | SCHERING CORPORATION (US) | 2009-12-29 | — | — | US | disclosed |
| US-20070167426-A1 | Compounds for the treatment of inflammatory disorders and microbial diseases | SCHERING CORPORATION | 2007-07-19 | — | — | US | disclosed |
| US-20060178366-A1 | Compounds for the treatment of inflammatory disorders | SCHERING CORPORATION | 2006-08-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167426-A1 | Compounds for the treatment of inflammatory disorders and microbial diseases | MMP12, ADAMTS1, ADAM33 | ASAH1 31/4885MGLL 588/4885MGAM 227/4885 |
| US-20060178366-A1 | Compounds for the treatment of inflammatory disorders | MMP12, ADAMTS1, TNF | ASAH1 37/4885MGLL 1313/4885MGAM 677/4885 |
| US-20100145048-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS | TNF, MMP12, MMP8 | ASAH1 42/4885MGLL 1323/4885MGAM 536/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.